Access our brochure on Hypha’s One-Stop Metabolite Services and Kits, which describes routes for accessing all the main types of phase I and phase II metabolites.
We use chemical synthesis, microbial biotransformation, mammalian tissue fractions (multiple species of S9s and microsomes) plus recombinant enzymes such as PolyCYPs, PolyUGTs, and human recombinant CYPs, AOX1 and FMOs 1 to 5.
- Phase 1 CYP and non-CYP metabolites
- Phase 2 metabolites, including O-, acyl, N- & N-carbamoyl glucuronides, sulfates and other conjugates
- Multiple metabolites and multistep metabolites
- Purification of metabolites
- Structure elucidation by NMR Spectroscopy
- Provision of Certificates of Analysis
- Scalable to multi-gram amounts
- Formulation know-how for poorly-soluble compounds
- Cold, stable-labelled and radiolabelled metabolites