Metabolite Tales Blog
Hypha’s “Metabolite Tales” blog articles are purely science-focussed commentary on interesting developments and papers relevant to the role of metabolism in drug discovery and development. The content is particularly relevant to those with a background in medicinal chemistry, drug metabolism and biotransformation.
We also recommend the following excellent blogs:
Drug Hunter – a trusted, independent source of curated, factual information for the drug discovery community, in particular the articles, case studies and cheat sheets!
In The Pipeline – Derek Lowe’s commentary on drug discovery and the pharma industry.
Hypha's Metabolite Tales Blog Articles
Our blog this month is inspired by a paper looking at the small but mighty impact of tertiary alcohols in drug design.
We follow on our last blog on active metabolites of 2024 FDA approved drugs with a quick look at what’s published about the metabolism of the newly approved non-opioid painkiller Suzetrigine, where a major active metabolite is also reported.
We kick off 2025 with a feature on metabolism of 2024 FDA approved small molecules. Part 1 highlights those with involvement of active metabolites.
Major biotransformation routes of aficamten involving hydroxylation, onwards glucuronidation and gut metabolism are highlighted and discussed in this article.
Two recent papers exploring the role of NMR spectroscopy in drug discovery and development have prompted us to highlight the role of NMR in drug metabolism in our blog this month.
Here we take a look at the growing knowledge about metabolism of targeted protein degraders drugs such as PROTACs.
In this next instalment we focus on drugs where metabolism in humans results in circulating glucuronides and other conjugates.
Over the next couple of months we’ll be taking a look at the metabolism of small molecule drugs approved by the FDA in 2023, starting with those where there is mention of the involvement of active metabolites.
In our last blog of the year, we look at why N-glucuronidation of small molecule drugs is important in human drug metabolism.
In this blog we delve into the metabolism of selected de novo-designed macrocyclic drugs approved by the FDA.
In this blog we look at motifs and scaffolds of F-containing drugs that are subject to metabolism mediated defluorination, along with some drug design strategies that have been used to circumvent this.
In this follow-up blog, we dig into the drugs approved by the FDA in 2022 that are cleared by multiple CYPs, mixed phase mechanisms and through involvement of gut metabolism.
Stay up to date with the latest news from Hypha Discovery
Sign up for our quarterly newsletters and monthly "Metabolite Tales" blog
Ready to begin? Our scientists are available to talk through your requirements
Hypha Discovery is a UK-based CRO supporting pharmaceutical and agrochemical companies worldwide through the production of metabolites and new derivatives of drugs and agrochemicals in discovery and development.