Metabolite Tales Blog

Hypha’s “Metabolite Tales” blog articles are purely science-focussed commentary on interesting developments and papers relevant to the role of metabolism in drug discovery and development. The content is particularly relevant to those with a background in medicinal chemistry, drug metabolism and biotransformation.

We also recommend the following excellent blogs:

Drug Hunter – a trusted, independent source of curated, factual information for the drug discovery community, in particular the articles, case studies and cheat sheets!

In The Pipeline – Derek Lowe’s commentary on drug discovery and the pharma industry.

Hypha's Metabolite Tales Blog Articles

We follow on our last blog on active metabolites of 2024 FDA approved drugs with a quick look at what’s published about the metabolism of the newly approved non-opioid painkiller Suzetrigine, where a major active metabolite is also reported.

Two recent papers exploring the role of NMR spectroscopy in drug discovery and development have prompted us to highlight the role of NMR in drug metabolism in our blog this month. 

In this blog we look at motifs and scaffolds of F-containing drugs that are subject to metabolism mediated defluorination, along with some drug design strategies that have been used to circumvent this.

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