Metabolite Tales Blog

Hypha’s “Metabolite Tales” blog articles are purely science-focussed commentary on interesting developments and papers relevant to the role of metabolism in drug discovery and development. The content is particularly relevant to those with a background in medicinal chemistry, drug metabolism and biotransformation.

We also recommend the following excellent blogs:

Drug Hunter – a trusted, independent source of curated, factual information for the drug discovery community, in particular the articles, case studies and cheat sheets!

In The Pipeline – Derek Lowe’s commentary on drug discovery and the pharma industry.

Hypha's Metabolite Tales Blog Articles

In this blog we look at motifs and scaffolds of F-containing drugs that are subject to metabolism mediated defluorination, along with some drug design strategies that have been used to circumvent this.

Andrew Parkinson, Consultant and former Founder and CSO/CEO at Xenotech, debates whether drugs that induce CYP1A enzymes via activation of the AhR receptor should be a cause for concern or not.

This blog highlights the prospect of exploiting orphan human CYPs for development of targeted anti-cancer agents through a prodrug strategy.

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