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In our Q4 2021 technical newsletter we describe how Hypha used PolyCYPs to help the Open Source Antibiotics team identify a drug metabolite.
We look at the synthesis of glucuronides and glucose conjugates in our Q3 2021 technical newsletter.
We discuss the synthesis of deuterated metabolites and purification of metabolites from complex mixtures in our Q2 2021 newsletter.
We’re pleased to welcome Dr Samuel Coe to the team at Hypha as Business Development Manager. Samuel is a medicinal chemist by training having previously worked in the pharma space for Vertex, Charnwood Molecular and Evotec.
Frank will be giving a talk at the EFMC-ISMC 2021 meeting on “Integration of Biocatalysis into Medicinal Chemistry Programs for Late-Stage Oxidised Derivatives using PolyCYPs Enzymes”
We’re proud of our team for the recent successful delivery of a client project using Hypha’s One-Stop Metabolite Shop approach. Metabolites of two drug substances were provided, using microbial biotransformation for one drug compound and late-stage chemical synthesis for the other.
We always really appreciate receiving feedback from a client. This time we celebrate project success for Alkermes for whom we used our PolarExplorer platform to deliver novel hydroxylated derivatives of some of their lead compounds. PolarExplorer uses Hypha’s PolyCYPs enzymes to create multiple hydroxylated derivatives of drugs in parallel.
Our newsletter for Q1 2021 features a commentary on the perceived increase in requests to access N-glucuronides, as well as highlighting Hypha’s solutions for synthesising and characterizing these and other types of glucuronide metabolites, as part of the tools in our One-Stop Metabolite Shop approach.
Project Manager and Head of Chemistry Richard Phipps, together with Hypha scientists Renia Gemmell, Chloe Herring and Chris Drake have received great feedback for the successful completion of a challenging metabolite project for a US pharma client. The project involved multiple disciplines of microbial biotransformation, purification and structure elucidation.
We’ve received some more positive feedback from one of our US pharma clients. Here’s what our client had to say:
We were delighted to welcome some new recruits to the Hypha family this October. Chloe Herring and John Boyle join the Chemistry team and Charlotte Woods joins the Microbiology team.
Hypha’s paper in ACS Medicinal Chemistry Letters on “Biotransformation: Impact and Application of Metabolism in Drug Discovery” was published in August 2020.
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Hypha Discovery is a UK-based CRO supporting pharmaceutical and agrochemical companies worldwide through the production of metabolites and new derivatives of drugs and agrochemicals in discovery and development.