Paper Picks

Take a look at our favourite publications around biotransformation and metabolism of drugs in Hypha’s “Paper Picks”.

Hypha's Paper Picks

Our paper pick for July 2024 highlights the the first-ever identification of an aldehyde oxidase-mediated DDI involving OSI-930 and inhibition of AO metabolism by erlotinib.

Our paper pick for April 2024 discusses the reasons and strategies for replacing a carboxylic acid with a bioisostere. Of particular interest is the use of structural biology to identify neutral bioisosteres that rely on less commonly explored cation π-interactions.

Our first paper pick for 2024 describes the discovery of IRAK4 inhibitors which benefited from inclusion of 2 hydroxyl groups at different positions in the structures.

Discover the recommendations made by the IQ Consortium Metabolite Bioanalysis Working Group around best practice in metabolite bioanalysis during drug development.

Concerned about missing or unexplained metabolites? Checkout our paper pick for October 2023 for helpful case studies and advice.

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