Download a brochure on Hypha’s new PolyUGTs kits.
PolyUGTs metabolite kits can be used to screen for, and scale-up production of, a variety of glucuronides of drugs, agrochemicals and other small molecules.
PolyUGT enzymes are mined from selected biotransforming strains in Hypha’s microbial collection, expressed in E.coli, and subsequently purified. The enzymes provided in the screening kit have been tested for biocatalytic activity against a number of substrates subject to glucuronidation. This includes glucuronidation of alkyl and phenolic hydroxyls for O-glucuronides, carboxylic acids for acyl-glucuronides, as well as aromatic nitrogen-containing systems for N-glucuronidation. Glucuronidation of some non-aromatic alkyl N-moieties is also observed.