Liam Evans will be presenting a poster at Drug Discovery Chemistry 2022. Taking place from April 18-21, 2022 in San Diego, Drug Discovery Chemistry is focused on discovery and optimization challenges of small molecule drug candidates.

Poster abstract

Routes for Synthesis of Metabolites of Ruxolitinib and Epacadostat

Significant metabolites of small molecule drugs sometimes need to be accessed at scale for further testing. Hypha have developed multiple techniques as part of their one-stop metabolite shop to tackle synthesis of these using both biotransformation and late-stage chemical synthesis methods.

In this poster we describe the routes taken to make metabolites of anticancer drugs, ruxolitinib and epacadostat, where the majority of metabolites were not accessible through facile chemical synthesis.

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