Integrated Metabolite Identification and Biocatalytic Synthesis: Case Studies with Repaglinide and PROTAC MZ-1

Abstract

Metabolite identification (MetID) is essential for understanding the metabolic fate of drugs in discovery and development. This poster illustrates an integrated workflow combining LC–MS/MS-based metabolite profiling and scalable biocatalysis with PolyCYPs® and PolyUGT enzymes, which facilitates rapid access to metabolites for structure elucidation by NMR, quantitation and biological profiling.

MetID case studies conducted in hepatocytes with repaglinide and the PROTAC tool molecule MZ-1 are used to illustrate the process.

For more information on Hypha’s MetID services or to discuss a project please contact us.