Abstract
PolyUGTs® are novel UDP-glucuronosyltransferases cloned from selected bacteria in Hypha’s biotransformation panel and developed into the PolyUGTs metabolite kit. The PolyUGTs screening kit currently contains 11 isoforms and hit reactions can be replicated using scale-up vials to obtain more material for structure elucidation and further studies.
This poster illustrates application of the kit to make O-, N-, acyl and N-carbamoyl glucuronides of small molecule drugs.
Poster presented by Dr Vincent Poon at Biotrans 2025, Basel, Switzerland