Scientific posters

This poster illustrates the process undertaken at Hypha to produce a major human metabolite of ingenol disoxate for regulatory compliance.

Microbial biotransformation offers an alternative and complementary approach to synthetic medicinal chemistry for the structural diversification of hit or lead compounds. Hypha Discovery has a scalable microbial process effective for activating C-H bonds to achieve aliphatic and aromatic hydroxylation. Applications include boosting ligand lipophilicity efficiency, improving selectivity, exploring SAR, creating handles for further derivatisation (e.g. fluorination for PET ligand formation or to block metabolism), or simply to highlight the conversion into active mammalian metabolites.