Small but mighty: the impact of tertiary alcohols in drug design
May 7, 2025 6:33 pm Leave your thoughtsSmall but mighty: the impact of tertiary alcohols in drug design By Julia Shanu-Wilson Creating a drug with perfect drug-like...
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Author Archives for Julia Shanu-Wilson
Q1 2025 – Launch of PolyUGTs Kits
March 13, 2025 10:02 am Leave your thoughtsLaunch of PolyUGTs Kits Our PolyUGTs screening and scale-up kits are now available! They’re a super easy way to make...
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Oxidative biotransformation of elinzanetant to 3 active metabolites
February 20, 2025 5:41 pm Leave your thoughtsOxidative biotransformation of elinzanetant to 3 active metabolites Elinzanetant is a dual neurokinin-1,3 receptor antagonist under development for treatment of...
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Welcome to Matt and Xianfu
February 20, 2025 9:02 am Leave your thoughtsWelcome to Matt and Xianfu We are delighted that Matthew Allen and Xianfu Li have joined Hypha’s team recently. Xianfu was previously at...
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Metabolism of the new pain drug Suzetrigine
February 7, 2025 3:35 pm Leave your thoughtsCYP3A-Mediated Metabolism of Suzetrigine By Julia Shanu-Wilson It’s been more than 20 years since a pain drug with a new...
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Metabolism of 2024 FDA Approved Small Molecules – PART 1
January 22, 2025 2:34 pm Leave your thoughtsMetabolism of 2024 FDA approved small molecules part 1 By Julia Shanu-Wilson Involvement of active metabolites The number of small...
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The Current State of Biotransformation Science 2024
December 12, 2024 5:34 pm Leave your thoughtsThe Current State of Biotransformation Science Industry Survey of In Vitro and In Vivo Practices, Clinical Translation, and Future Trends...
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Q4 2024 Newsletter – Accessing glucuronides, new UGT kit, and latest blog
December 11, 2024 11:13 am Leave your thoughtsHypha’s Q4 2024 Newsletter – Accessing glucuronides, a new UGT kit and our latest paper picks and blog article Focus topics...
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Major biotransformation routes of aficamten
November 13, 2024 11:56 am Leave your thoughtsMajor biotransformation routes of aficamten involving hydroxylation, onwards glucuronidation and gut metabolism Hypertrophic cardiomyopathy is a surprisingly common genetic heart...
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Major circulating glucuronides of icenticaftor
October 10, 2024 2:04 pm Leave your thoughtsMajor circulating glucuronides of icenticaftor This paper from scientists at Novartis describes the human ADME characteristics of icenticaftor and its...
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