Bioisosteres for carboxylic acid groups Carboxylic acid containing drugs – opportunities for substituting bioisosteres to mitigate the formation of acyl...
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Metabolism of 2023 FDA Approved Small Molecules – PART 2 A focus on drugs where metabolism in humans results in...
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Aldehyde oxidase metabolite toxicity This month we highlight a paper describing a project in which toxicity arising from metabolite-mediated prolongation...
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Metabolism-mediated loss of radiolabel during human mass balance studies Our choice for February comprises two papers concerned with the impact...
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Senior Purification Chemist Hypha Discovery has an exciting opportunity for an experienced purification chemist to join our team to work...
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Beneficial Hydroxyl Substitution This paper from scientists at Bayer describes the discovery of two IRAK4 inhibitors. There are many aspects...
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Metabolism of 2023 FDA Approved Small Molecules – PART 1 By Julia Shanu-Wilson 2023 was a fruitful year for new...
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Hypha’s Q4 2023 Newsletter – Late-stage oxidation and deoxyfluorination In our Q4 2023 newsletter we give you a sneek peek...
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Metabolite Bioanalysis in Drug Development: Recommendations from the IQ Consortium Metabolite Bioanalysis Working Group A Metabolite Bioanalysis Working Group composed...
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N-glucuronidation: the human element By Julia Shanu-Wilson In our last blog of the year, we look at why N-glucuronidation of...
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