Aldehyde oxidase metabolite toxicity This month we highlight a paper describing a project in which toxicity arising from metabolite-mediated prolongation...
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Metabolism-mediated loss of radiolabel during human mass balance studies Our choice for February comprises two papers concerned with the impact...
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Beneficial Hydroxyl Substitution This paper from scientists at Bayer describes the discovery of two IRAK4 inhibitors. There are many aspects...
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Metabolism of 2023 FDA Approved Small Molecules – PART 1 By Julia Shanu-Wilson 2023 was a fruitful year for new...
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Hypha’s Q4 2023 Newsletter – Late-stage oxidation and deoxyfluorination In our Q4 2023 newsletter we give you a sneek peek...
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Metabolite Bioanalysis in Drug Development: Recommendations from the IQ Consortium Metabolite Bioanalysis Working Group A Metabolite Bioanalysis Working Group composed...
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N-glucuronidation: the human element By Julia Shanu-Wilson In our last blog of the year, we look at why N-glucuronidation of...
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Unusual gut metabolites For drugs that are locally acting, prominent metabolites in the target organ may be just as significant...
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Missing metabolites Accounting for metabolites is a key activity in drug development programs. Sometimes biotransformations result in metabolites that might...
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Unusual biotransformation reactions uncovered by scientists at Genentech This compilation of 10 case studies arising from work done at Genentech...
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