The Current State of Biotransformation Science Industry Survey of In Vitro and In Vivo Practices, Clinical Translation, and Future Trends...
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Hypha’s Q4 2024 Newsletter – Accessing glucuronides, a new UGT kit and our latest paper picks and blog article Focus topics...
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Major biotransformation routes of aficamten involving hydroxylation, onwards glucuronidation and gut metabolism Hypertrophic cardiomyopathy is a surprisingly common genetic heart...
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Major circulating glucuronides of icenticaftor This paper from scientists at Novartis describes the human ADME characteristics of icenticaftor and its...
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Hypha’s Q3 2024 Newsletter – Metabolism of degraders, gut metabolites, qNMR and more Focus topics for this edition: Metabolism of...
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NMR: An indispensable ADME tool We highlight two recent papers this month, both of which feature the role of NMR...
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Discovery of unprecedented human stercobilin conjugates of inavolisib Our highlighted paper this month is one in which Hypha worked with...
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Metabolism of PROTACs Common biotransformation pathways By Julia Shanu-Wilson Heterobifunctional protein degraders such as proteolysis targeting chimeras (PROTACs) comprise a...
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First-ever identification of an aldehyde oxidase-mediated DDI Inhibition of aldehyde oxidase mediated metabolism of OS1-930 by erlotinib Where metabolic pathways...
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Impact of a single biotransformation leading to intramolecular reactions and chemical degradation Through CYP-mediated oxidation of a pyrazole group Our...
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