Major circulating glucuronides of icenticaftor This paper from scientists at Novartis describes the human ADME characteristics of icenticaftor and its...
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Hypha’s Q3 2024 Newsletter – Metabolism of degraders, gut metabolites, qNMR and more Focus topics for this edition: Metabolism of...
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NMR: An indispensable ADME tool We highlight two recent papers this month, both of which feature the role of NMR...
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Discovery of unprecedented human stercobilin conjugates of inavolisib Our highlighted paper this month is one in which Hypha worked with...
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Metabolism of PROTACs Common biotransformation pathways By Julia Shanu-Wilson Heterobifunctional protein degraders such as proteolysis targeting chimeras (PROTACs) comprise a...
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First-ever identification of an aldehyde oxidase-mediated DDI Inhibition of aldehyde oxidase mediated metabolism of OS1-930 by erlotinib Where metabolic pathways...
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Impact of a single biotransformation leading to intramolecular reactions and chemical degradation Through CYP-mediated oxidation of a pyrazole group Our...
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Hypha’s Q2 2024 Newsletter – Focus on N-glucuronidation N-glucuronides may emerge as disproportionate metabolites due to interspecies variability and higher...
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Bioisosteres for carboxylic acid groups Carboxylic acid containing drugs – opportunities for substituting bioisosteres to mitigate the formation of acyl...
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Metabolism of 2023 FDA Approved Small Molecules – PART 2 A focus on drugs where metabolism in humans results in...
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