Learn about the application of PolyCYPs enzymes for late-stage oxidation in Hypha’s PolarExplorer brochure.
Hypha’s PolarExplorer late-stage functionalisation service delivers multiple oxidised derivatives of drugs and other small molecules through biocatalysis.
PolarExplorer uses PolyCYPs® enzymes to provide a quick late-stage route to hydroxylate aliphatic or aromatic moieties at multiple sites in parallel, including metabolically susceptible positions. Both CYP-derived human metabolites and other oxidised derivatives can then be accessed simultaneously for structure elucidation and biological testing.
PolarExplorer Benefits
- Produce derivatives with improved potency or selectivity
- Identify CYO mediated metabolites and metabolic hot spots
- Probe for beneficial polar interactions
- Improve DMPK properties
- Expand SAR understanding and exemplify active metabolites in patents