We are excited to announce the official launch of our One-Stop Metabolite Shop, which offers a complete solution for pharma and agrochemical companies to access small molecule metabolites.
As part of this umbrella service, we offer a comprehensive suite of techniques for provision of even the most difficult-to-synthesise metabolite, comprising chemical synthesis, recombinant enzymes, microbial biotransformation, mammalian liver fractions as well as the purification of metabolites from biological matrices.
Our latest developments include the launch of our PolyCYPs®+ screening kits and a new late-stage chemical glucuronidation screen, suitable for synthesis of O-, N-, N-carbamoyl and acyl glucuronides.
The chemical screen features tailored deprotection strategies to improve the synthesis of acyl glucuronides and some unstable N-glucuronides, and is complementary to our existing successful microbial and mammalian biotransformation routes for generating metabolites.
The extended PolyCYPs®+ kits comprise 18 diverse CYP isoforms cloned from some of Hypha’s bacteria, as well as complimentary inclusion of two other phase 1 enzymes – human aldehyde oxidase (AOX1) and flavin monooxygenase 3 (FMO3), with other FMO isoforms to be incorporated as they become available.
