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We always really appreciate receiving feedback from a client. This time we celebrate project success for Alkermes for whom we used our PolarExplorer platform to deliver novel hydroxylated derivatives of some of their lead compounds. PolarExplorer uses Hypha’s PolyCYPs enzymes to create multiple hydroxylated derivatives of drugs in parallel.

Project Manager and Head of Chemistry Richard Phipps, together with Hypha scientists Renia Gemmell, Chloe Herring and Chris Drake have received great feedback for the successful completion of a challenging metabolite project for a US pharma client. The project involved multiple disciplines of microbial biotransformation, purification and structure elucidation.

Hypha were honoured to be asked to contribute a chapter on “Metabolite Generation and Metabolite Characterization by NMR” in the book just published on “Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters”, edited by Shuguang Ma and Swapan Chowdhury.

Hypha are excited to announce they have relocated from Slough to Milton Park in Oxfordshire, one of the largest science clusters in the UK.

Metabolites derived from any human flavin-containing monooxygenase (FMO) subtype can now be produced as a service offering at Hypha. Recombinant enzymes of all five forms of human FMOs have been cloned into E.coli to provide a mechanism to access scalable quantities of FMO derived metabolites.

Hypha remain fully operational and are monitoring the COVID-19 situation closely. We have implemented a number of measures in response to the guidelines issued by the UK Government to ensure that our clients’ projects proceed as planned, while preserving the health and safety of our staff and the wider community.

As a leading specialist CRO for drug metabolite provision, Hypha has formed a partnership with Cypex Limited, experts in the provision of a variety of recombinant xenobiotic metabolising enzymes, wherein Hypha will scale-up and purify metabolites made by Cypex enzymes.

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