Q3 2026 Newsletter – Gut metabolism, PROTAC MetID update and latest blog
Explore the latest from Hypha in our Q3 2026 newsletter:
💡 Highlights
- Gut Metabolism Research: Discovering key gut metabolites of drugs using controlled anaerobic human faecal incubations. We highlight two case studies involving metabolism of ozanimod and inavolisib. Download a poster on the two case studies presented at the DMDG-GMP-SPS Joint Meeting in Prague.
- PROTAC MetID Update: Structure elucidation of an oxidised metabolite of PROTAC MZ1 using PolyCYPs enzymes to scale up synthesis for NMR spectroscopy.
- Latest blog post “When spirocycles become metabolic soft spots”: Spirocycles can bring valuable three-dimensionality, tune physicochemical properties and even improve metabolic stability. But what happens when the spirocycle itself becomes a weak point? Muvadenant offers an interesting case study, with metabolism studies revealing oxidative ring opening across two different ring systems
- Upcoming Conferences: Connect with the Hypha team at the ISSX meeting in San Francisco at Booth #207.
We can tailor MetID and metabolite synthesis packages to your requirements.
📩 Get in touch to learn more .
