Q1 2026 Newsletter – LC/MS-MS MetID Service
Hypha provides a high quality LC-MS/MS based MetID Service to complement our existing definitive MetID capabilities using NMR spectroscopy. This allows MetID strategy, structural confirmation, and material generation to be addressed within a single, coherent workflow with us at Hypha.
We support:
- In-depth biotransformation studies using multi-species hepatocytes, microsomes and related systems, including systems for slowly metabolised compounds
- LC-MS/MS-based metabolite identification to guide prioritisation and strategy
- Definitive structure elucidation at microgram scale using cryoprobe NMR spectroscopy
- Identification of metabolic soft spots to inform medicinal chemistry and risk assessment
- Milligram-gram scale of metabolites of all types to support downstream studies using biotransformation or chemical synthesis approaches
Free metabolite synthesis screening
For full Met-ID projects, we uniquely offer complementary PolyCYPs and PolyUGTs screening, which we have seen to provide additional context when advising clients on metabolite generation strategies, whether the goal is definitive identification or scaling material for downstream studies such as synthesis, safety assessment, or quantitative bioanalysis of metabolites.
We can tailor the MetID package to your requirements, contact us to find out more.
