Hypha’s Q3 2024 Newsletter – Metabolism of degraders, gut metabolites, qNMR and more
Focus topics for this edition:
- Metabolism of targeted protein degraders drugs such as PROTACs.
- Novel fecal metabolites of inavolisib (GDC-0077).
- The role of NMR spectroscopy in drug metabolism studies. In the article we briefly discuss:
- ADME applications of NMR
- Use of 19F-NMR and mass spec as an alternative to traditional ADME studies
- Cryoprobe technology
- Quantitative NMR
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