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Q3 2024 Newsletter – Metabolism of degraders, gut metabolites, qNMR and more

Hypha’s Q3 2024 Newsletter – Metabolism of degraders, gut metabolites, qNMR and more

Focus topics for this edition:

  • Metabolism of targeted protein degraders drugs such as PROTACs.
  • Novel fecal metabolites of inavolisib (GDC-0077).
  • The role of NMR spectroscopy in drug metabolism studies. In the article we briefly discuss:
    • ADME applications of NMR
    • Use of 19F-NMR and mass spec as an alternative to traditional ADME studies
    • Cryoprobe technology
    • Quantitative NMR

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