Biocatalytic paths to synthesis of Iptacopan metabolites
June 6, 2025 12:44 pm Leave your thoughtsBiocatalytic paths to the synthesis of selected metabolites of Iptacopan In a recent paper published in celebration of the 20th...
View Article
Author Archives for Julia Shanu-Wilson
Small but mighty: the impact of tertiary alcohols in drug design
May 7, 2025 6:33 pm Leave your thoughtsSmall but mighty: the impact of tertiary alcohols in drug design By Julia Shanu-Wilson Creating a drug with perfect drug-like...
View Article
Q1 2025 – Launch of PolyUGTs Kits
March 13, 2025 10:02 am Leave your thoughtsLaunch of PolyUGTs Kits Our PolyUGTs screening and scale-up kits are now available! They’re a super easy way to make...
View Article
Oxidative biotransformation of elinzanetant to 3 active metabolites
February 20, 2025 5:41 pm Leave your thoughtsOxidative biotransformation of elinzanetant to 3 active metabolites Elinzanetant is a dual neurokinin-1,3 receptor antagonist under development for treatment of...
View Article
Welcome to Matt and Xianfu
February 20, 2025 9:02 am Leave your thoughtsWelcome to Matt and Xianfu We are delighted that Matthew Allen and Xianfu Li have joined Hypha’s team recently. Xianfu was previously at...
View Article
Metabolism of the new pain drug Suzetrigine
February 7, 2025 3:35 pm Leave your thoughtsCYP3A-Mediated Metabolism of Suzetrigine By Julia Shanu-Wilson It’s been more than 20 years since a pain drug with a new...
View Article
Metabolism of 2024 FDA Approved Small Molecules – PART 1
January 22, 2025 2:34 pm Leave your thoughtsMetabolism of 2024 FDA approved small molecules part 1 By Julia Shanu-Wilson Involvement of active metabolites The number of small...
View Article
The Current State of Biotransformation Science 2024
December 12, 2024 5:34 pm Leave your thoughtsThe Current State of Biotransformation Science Industry Survey of In Vitro and In Vivo Practices, Clinical Translation, and Future Trends...
View Article
Q4 2024 Newsletter – Accessing glucuronides, new UGT kit, and latest blog
December 11, 2024 11:13 am Leave your thoughtsHypha’s Q4 2024 Newsletter – Accessing glucuronides, a new UGT kit and our latest paper picks and blog article Focus topics...
View Article
Major biotransformation routes of aficamten
November 13, 2024 11:56 am Leave your thoughtsMajor biotransformation routes of aficamten involving hydroxylation, onwards glucuronidation and gut metabolism Hypertrophic cardiomyopathy is a surprisingly common genetic heart...
View Article