Brochure

One-stop Metabolite Shop Brochure

Access our brochure on Hypha’s One-Stop Metabolite Shop, which describes how we synthesise, purify and characterise all the main types of mammalian phase 1 and 2 metabolites.

We use chemical synthesis, microbial biotransformation, mammalian tissue fractions (multiple species of S9s and microsomes) plus recombinant enzymes such as PolyCYPs, and human recombinant CYPs, AOX1 and FMOs 1 to 5.

  • Phase 1 CYP and non-CYP metabolites
  • Phase 2 metabolites, including O-, acyl, N- & N-carbamoyl glucuronides, sulfates and other conjugates
  • Multiple metabolites and multistep metabolites
  • Purification of metabolites
  • Structure elucidation by NMR Spectroscopy
  • Provision of Certificates of Analysis
  • Scalable to multi-gram amounts
  • Formulation know-how for poorly-soluble compounds
  • Cold, stable-labelled and radiolabelled metabolites

Ready to begin? Our scientists are available to talk through your requirements

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