Latest News

Check out a new white paper describing the joint efforts of Hypha and Galchimia, who together successfully synthesised metabolites of the herbicide napropamide using a complementary approach of chemical synthesis and microbial biotransformation. The joint project was successful in providing a comprehensive family of compounds relevant for the risk assessment of napropamide.

Hypha were honoured to be asked to contribute a chapter on “Metabolite Generation and Metabolite Characterization by NMR” in the book just published on “Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters”, edited by Shuguang Ma and Swapan Chowdhury.

Hypha are excited to announce they have relocated from Slough to Milton Park in Oxfordshire, one of the largest science clusters in the UK.

Metabolites derived from any human flavin-containing monooxygenase (FMO) subtype can now be produced as a service offering at Hypha. Recombinant enzymes of all five forms of human FMOs have been cloned into E.coli to provide a mechanism to access scalable quantities of FMO derived metabolites.

Hypha remain fully operational and are monitoring the COVID-19 situation closely. We have implemented a number of measures in response to the guidelines issued by the UK Government to ensure that our clients’ projects proceed as planned, while preserving the health and safety of our staff and the wider community.

As a leading specialist CRO for drug metabolite provision, Hypha has formed a partnership with Cypex Limited, experts in the provision of a variety of recombinant xenobiotic metabolising enzymes, wherein Hypha will scale-up and purify metabolites made by Cypex enzymes.

We are excited to announce the official launch of our One-Stop Metabolite Shop, which offers a complete solution for pharma and agrochemical companies to access small molecule metabolites.

Hypha is able to offer clients a combination of a number of biological and chemical techniques, meaning that clients can quickly establish a method to identify and scale up any type of metabolite.


Our newsletter this quarter looks at the use of microbial biotransformation to synthesize glucuronide metabolites, with a particular emphasis on the production of acyl glucuronides, arising from the metabolism of carboxylic acid-containing drugs.

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