Metabolism of PROTACs Common biotransformation pathways By Julia Shanu-Wilson Heterobifunctional protein degraders such as proteolysis targeting chimeras (PROTACs) comprise a...
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First-ever identification of an aldehyde oxidase-mediated DDI Inhibition of aldehyde oxidase mediated metabolism of OS1-930 by erlotinib Where metabolic pathways...
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Impact of a single biotransformation leading to intramolecular reactions and chemical degradation Through CYP-mediated oxidation of a pyrazole group Our...
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Hypha’s Q2 2024 Newsletter – Focus on N-glucuronidation N-glucuronides may emerge as disproportionate metabolites due to interspecies variability and higher...
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Bioisosteres for carboxylic acid groups Carboxylic acid containing drugs – opportunities for substituting bioisosteres to mitigate the formation of acyl...
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Metabolism of 2023 FDA Approved Small Molecules – PART 2 A focus on drugs where metabolism in humans results in...
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Aldehyde oxidase metabolite toxicity This month we highlight a paper describing a project in which toxicity arising from metabolite-mediated prolongation...
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Metabolism-mediated loss of radiolabel during human mass balance studies Our choice for February comprises two papers concerned with the impact...
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Beneficial Hydroxyl Substitution This paper from scientists at Bayer describes the discovery of two IRAK4 inhibitors. There are many aspects...
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Metabolism of 2023 FDA Approved Small Molecules – PART 1 By Julia Shanu-Wilson 2023 was a fruitful year for new...
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