Q4 2022 Newsletter – Deuterated Metabolites
December 2, 2022 4:41 pm Leave your thoughtsHypha’s Q4 2022 newsletter – synthesis of deuterated metabolites In our Q4 2022 newsletter we look at how Hypha make...
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Author Archives for Julia Shanu-Wilson
AhR activators – friend or foe?
November 17, 2022 4:34 pm Leave your thoughtsAhR activators – friend or foe? A very usual metabolite, a very unusual pharmacological target, and an unexpected serious adverse...
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Covalent drugs: metabolism stories
October 12, 2022 12:47 pm Leave your thoughtsMetabolism of covalent drugs: Stories from a resurgent field By Samuel Coe With the successful launch of Amgen’s targeted KRAS-blocking...
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Q3 2022 Newsletter – Gut metabolites and unexpected conjugates
October 5, 2022 12:08 pm Leave your thoughtsHypha’s Q3 2022 newsletter – gut metabolites and unexpected conjugates In Hypha’s Q3 2022 newsletter we feature our new gut...
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Bioisosteres that influence metabolism
July 13, 2022 1:19 pm 1 CommentBioisosteres that influence metabolism By Samuel Coe The majority of reviews on the application of bioisosteres are focused on effects...
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Q2 2022 Newsletter – GSH conjugates, metabolite purification, and late-stage oxidation kits
July 5, 2022 3:36 pm Leave your thoughtsHypha’s Q2 2022 newsletter – GSH conjugates using PolyCYPs enzymes, metabolite purification case studies, and late-stage oxidation kits In Hypha’s...
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Metabolism of t-butyl groups in drugs
May 18, 2022 5:36 pm Leave your thoughtsMetabolism of t-butyl groups in drugs: t for trouble? By Julia Shanu-Wilson The tert-butyl group is a common group present...
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Orphan CYPs: homing In
April 13, 2022 8:48 am Leave your thoughtsOrphan CYPs – finding a home in personalised medicine By Samuel Coe Cytochrome P450 enzymes (CYPs) are responsible for the...
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The underappreciated hydroxyl in drug discovery
February 28, 2022 6:36 pm Leave your thoughtsThe underappreciated hydroxyl in drug discovery By Rob Young Here we explore some of the potential impacts of hydroxyl groups...
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Q1 2022 Newsletter – API degradation products and impurities
February 16, 2022 12:42 pm Leave your thoughtsQ1 2022 Newsletter – API degradation products and steroid metabolism Our new service for accessing API degradation products and impurities...
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