Orphan CYPs: homing In
April 13, 2022 8:48 am Leave your thoughtsOrphan CYPs – finding a home in personalised medicine By Samuel Coe Cytochrome P450 enzymes (CYPs) are responsible for the...
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Author Archives for Julia Shanu-Wilson
The underappreciated hydroxyl in drug discovery
February 28, 2022 6:36 pm Leave your thoughtsThe underappreciated hydroxyl in drug discovery By Rob Young Here we explore some of the potential impacts of hydroxyl groups...
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Q1 2022 Newsletter – API degradation products and impurities
February 16, 2022 12:42 pm Leave your thoughtsQ1 2022 Newsletter – API degradation products and steroid metabolism Our new service for accessing API degradation products and impurities...
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A checklist for drug candidate selection
January 19, 2022 5:50 pm Leave your thoughtsToday’s Medicinal Chemist – a checklist for Candidate selection By Steve Djuric Many (many) years ago as a fledgling medicinal...
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De-risking DMPK: what’s key?
December 14, 2021 6:39 pm Leave your thoughtsDe-risking DMPK: what’s key? By Guy Webber Drugs can fail i) before they enter clinical development in humans ii) during...
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CYP2J2: an epoxygenase worth bothering about?
December 1, 2021 3:55 pm Leave your thoughtsCYP2J2: An epoxygenase worth bothering about? By Julia Shanu-Wilson CYP2J2 snuck into last place in the breakdown by Zanger and...
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Q4 2021 Newsletter – Metabolite identification by PolyCYPs and Kit Offer
November 18, 2021 5:02 pm Leave your thoughtsQ4 2021 Newsletter – Metabolite identification by PolyCYPs and 20% off Kit Offer Metabolite identification by PolyCYPs – in our...
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Q2 2021 Newsletter – Deuterated metabolites
November 10, 2021 9:10 am Leave your thoughtsWe discuss the synthesis of deuterated metabolites and purification of metabolites from complex mixtures in our Q2 2021 technical newsletter....
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LipMetE – A useful tool for relating lipophilicity to metabolic stability in microsomes?
October 28, 2021 3:44 pm Leave your thoughtsLipMetE – A useful tool for relating lipophilicity to metabolic stability in microsomes? By Samuel Coe LipMetE is a potentially...
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Metabolism of cyclopropyl groups
September 23, 2021 7:33 pm Leave your thoughtsMetabolism of cyclopropyl groups: a double-edged sword By Julia Shanu-Wilson Cyclopropyl groups are an appealing substituent to use in drug...
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